Structural genomics on metalloproteins

X-ray structural studies of some metalloproteins

Metalloproteins are an important class of proteins and perform a variety of biological processes. They are ideally suited for Synchrotron Radiation studies. In particular, X-ray region of the spectrum has been very effectively exploited not only for crystallographic structure determinations but X-ray absorption fine structure (XAFS) and more recently X-ray solution scattering techniques have al...

Structural Genomics on the Web

In this review we provide a brief guide to some of the resources and databases that can be used to locate information and aid research in the growing field of structural genomics. The review will provide examples, for less experienced users, of what can be achieved using a selection of the available sites. We hope that this will encourage you to use these sites to their full potential and whet ...

Structural genomics

theory, based on the shape and location of coral formations, on coral’s inability to grow at depths greater than 30 fathoms, and most of all on a scenario for which he had no evidence: that each reef or atoll represents the outer limit of an island that has slowly subsided into the ocean. Read this chapter, if only to be struck by its masterly fusion of acute observation and trenchant imaginati...

De novo design and structural characterization of proteins and metalloproteins.

De novo protein design has recently emerged as an attractive approach for studying the structure and function of proteins. This approach critically tests our understanding of the principles of protein folding; only in de novo design must one truly confront the issue of how to specify a protein's fold and function. If we truly understand proteins, it should be possible to design receptors, enzym...

Bioinformatics in structural genomics.